反应详情

General Procedure D. To a solution of 1-(1-benzyl-2-isopropyl-5-(tetrahydropyran-2-yloxy)-1H-indol-3-yl)ethanone (Compound 14, 60 mg, 0.16 mmol) in MeOH was added aq. HCl (1 mL), and the solution was stirred for 5 min. at room temperature. The reaction was quenched by adding 5% aqueous NaHCO3 (2 mL), and the product was extracted with EtOAc (30 mL). The organic layer was separated, and washed with water, and brine, and dried (Na2SO4), and the solvent was removed under vacuum. Flash chromatography on silica gel with 20% EtOAc in hexane gave 1-(1-benzyl-5-hydroxy-2-isopropyl-1H-indol-3-yl)ethanone (Compound 17) as a white solid.

1. customThe reaction was quenched
2. additionby adding 5% aqueous NaHCO3 (2 mL)
3. extractionthe product was extracted with EtOAc (30 mL)
4. customThe organic layer was separated
5. washwashed with water, and brine
6. dry with materialdried (Na2SO4)
7. customthe solvent was removed under vacuum