反应详情

温度

60 °C

Dissolve 1.9 g (4.86 mmol) of the product obtained in Step 1 in 30 ml of ethanol and add to that solution 7 ml (24.3 mmol, 5 equivalents) of HCl in ethanol (3.5N). Heat overnight at 60° C. and evaporate the reaction mixture to dryness. The residue obtained is taken up in water, and the aqueous phase is then adjusted to pH=8 by adding 20% sodium hydroxide solution and extracted with dichloromethane. The organic phase is washed with water, dried over MgSO4, filtered and then evaporated to dryness. 1.1 g of the title product are obtained in the form of a colourless oil.

1. customevaporate the reaction mixture to dryness
2. customThe residue obtained
3. extractionextracted with dichloromethane
4. washThe organic phase is washed with water
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated to dryness