Meropenem → Meropenem Trihydrate

HRID 420871Notes

Reaction equation

HRID 420871 reaction equation
[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH2:12]2)=[C:8]([C:21]([OH:23])=[O:22])[N:7]2[C@H:3]1[C@@H:4]([C@H:24]([OH:26])[CH3:25])[C:5]2=[O:6]>O.[Pd]>[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([N:18]([CH3:19])[CH3:20])=[O:17])[CH2:12]2)=[C:8]([C:21]([OH:23])=[O:22])[N:7]2[C@H:3]1[C@@H:4]([C@H:24]([OH:26])[CH3:25])[C:5]2=[O:6].[OH2:6].[OH2:6].[OH2:6]

Participants

4

Reactant 1

HCID 441130Meropenem

Product 1

HCID 441129Meropenem Trihydrate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

In another aspect, the deprotection of protected meropenem is achieved by hydrogenation at atmospheric pressure in mixture of tetrahydrofuron and water as solvent media with palladium on charcoal at room temperature at pH of reaction mass 6.5 to 7.5 to get meropenem trihydrate in desirable yield and purity.

Workup

  1. customat pH of reaction mass 6.5 to 7.5

Sources & evidence

ORD record
ord-ab251bb00bdb42d0926255f2a03c83f1
Source dataset
uspto-grants-2012_01
Patent number
US08097719B2

Reaction notes

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