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HRID420871

反应详情

EQUATION

反应方程式

HRID 420871 的结构方程式

REACTANTS

反应物

1
结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)[C@H](C)[C@H]12
HCID441130

Meropenem

C17H25N3O5S

PRODUCTS

生成物

1
结构：C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)[C@H](C)[C@H]12.O.O.O
HCID441129

Meropenem trihydrate

C17H31N3O8S

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In another aspect, the deprotection of protected meropenem is achieved by hydrogenation at atmospheric pressure in mixture of tetrahydrofuron and water as solvent media with palladium on charcoal at room temperature at pH of reaction mass 6.5 to 7.5 to get meropenem trihydrate in desirable yield and purity.

WORKUP

后处理

  1. customat pH of reaction mass 6.5 to 7.5