HuagongsheHuagongshe Chemistry Print Report · For research reference only
Meropenem → Meropenem Trihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Meropenem | HCID 441130 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | Meropenem Trihydrate | HCID 441129 | — |
Reaction Steps
In another aspect, the deprotection of protected meropenem is achieved by hydrogenation at atmospheric pressure in mixture of tetrahydrofuron and water as solvent media with palladium on charcoal at room temperature at pH of reaction mass 6.5 to 7.5 to get meropenem trihydrate in desirable yield and purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097719B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ab251bb00bdb42d0926255f2a03c83f1 |
| Source note | uspto-grants-2012_01 |