HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(4-amino-2-chloropyridin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-amino-2-chloropyridin-3-yl)acetamide | HCID 45119288 | — |
Reaction Steps
1.1 A solution of 10.0 g of 3,4-diamino-2-chloropyridine and 6.62 ml of acetic anhydride in 100 ml of THF is stirred at room temperature for 16 hours. The product is separated off and dried, giving 7.3 g of N-(4-amino-2-chloropyridin-3-yl)acetamide (“1”).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097727B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-855e4986caed43f8929211014d5c50e5 |
| Source note | uspto-grants-2012_01 |