反应详情

A mixture of 1-(4-diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester (200 mg, 0.46 mmol, see step (b) above), Cu(OAc)2 (83 mg, 0.46 mmol), 4-trifluoromethylbenzeneboronic acid (129 mg, 0.68 mmol), pyridine (55 μL, 0.68 mmol), Et3N (94 μL, 0.68 mmol), molecular sieves 4 Å and anhydrous CH2Cl2 (10 mL) was stirred at rt for 2 d, filtered, concentrated and purified by chromatography to give the sub-title compound. Yield 150 mg, 56%.

1. filtrationfiltered
2. concentrationconcentrated
3. custompurified by chromatography