Sodium Hydroxide → HCID 66657683, compound

HRID 420937Notes

Reaction equation

HRID 420937 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[C:21]([C:22]#[N:23])=[CH:20][CH:19]=[C:18]([CH3:24])[N:17]=3)[CH:13]=2)[N:8]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH:32]([CH3:34])[CH3:33])=[CH:27][CH:26]=2)[C:7]=1[CH2:35][C:36]([O:38]CC)=[O:37])=[O:5])[CH3:2].[OH-].[Na+]>CCO>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[C:21]([C:22]#[N:23])=[CH:20][CH:19]=[C:18]([CH3:24])[N:17]=3)[CH:13]=2)[N:8]([C:25]2[CH:26]=[CH:27][C:28]([O:31][CH:32]([CH3:33])[CH3:34])=[CH:29][CH:30]=2)[C:7]=1[CH2:35][C:36]([OH:38])=[O:37])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66657996HCID 66657996, compound

Product 1

HCID 66657683HCID 66657683, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Ethoxycarbonylmethyl-5-(3-cyano-6-methyl-2-pyridin-yloxy)-1-(4-isopropoxyphenyl)-indole-3-carboxylic acid ethyl ester (275 mg, 0.51 mmol, see step (a) above), 1 M NaOH (aq, 1 M, 1.52 mL) and EtOH (3 mL) was heated at 50° C. for 1 h. The title compound was isolated as described before. Yield 203 mg (77%), mp 179° C.

Sources & evidence

ORD record
ord-bd3339cc44f84966b7ec68a94b5e5493
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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