HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 66657683, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 66657996 | HCID 66657996 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 66657683 | HCID 66657683 | — |
Reaction Steps
2-Ethoxycarbonylmethyl-5-(3-cyano-6-methyl-2-pyridin-yloxy)-1-(4-isopropoxyphenyl)-indole-3-carboxylic acid ethyl ester (275 mg, 0.51 mmol, see step (a) above), 1 M NaOH (aq, 1 M, 1.52 mL) and EtOH (3 mL) was heated at 50° C. for 1 h. The title compound was isolated as described before. Yield 203 mg (77%), mp 179° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097623B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-bd3339cc44f84966b7ec68a94b5e5493 |
| Source note | uspto-grants-2012_01 |