Sodium Hydroxide → HCID 66657660, compound

HRID 420984Notes

Reaction equation

HRID 420984 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[CH:13]=2)[N:8]([C:27]2[CH:32]=[CH:31][C:30]([N:33]([CH2:36][CH3:37])[CH2:34][CH3:35])=[CH:29][CH:28]=2)[C:7]=1[CH2:38][C:39]([O:41]CC)=[O:40])=[O:5])[CH3:2].[OH-].[Na+]>O1CCOCC1>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:17]=[CH:18][C:19]([O:22][C:23]([F:26])([F:24])[F:25])=[CH:20][CH:21]=3)[CH:13]=2)[N:8]([C:27]2[CH:28]=[CH:29][C:30]([N:33]([CH2:36][CH3:37])[CH2:34][CH3:35])=[CH:31][CH:32]=2)[C:7]=1[CH2:38][C:39]([OH:41])=[O:40])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66657737HCID 66657737, compound

Product 1

HCID 66657660HCID 66657660, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1-(4-Diethylaminophenyl)-2-ethoxycarbonylmethyl-5-(4-trifluoromethoxyphenoxy)indole-3-carboxylic acid ethyl ester (150 mg, 0.25 mmol, see step (a) Example 75) was hydrolysed at 55° C. for 3 h with NaOH (aq, 2 M, 2 mL) and dioxane (2 mL). Work-up as described in step (d) Example 1 gave the title compound. Yield 110 mg (77%).

Sources & evidence

ORD record
ord-a99ff54029384bcb8504159f18e75d74
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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