1-Hydroxy-2-naphthoic acid → HCID 11741624, compound

HRID 421019Notes

Reaction equation

HRID 421019 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=O.[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[NH2:20]>>[F:15][C:16]([F:28])([F:29])[C:17]1[CH:18]=[C:19]([NH:20][C:12]([C:3]2[CH:4]=[CH:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:2]=2[OH:1])=[O:14])[CH:21]=[C:22]([C:24]([F:25])([F:27])[F:26])[CH:23]=1

Participants

3

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

Product 1

HCID 11741624HCID 11741624, compoundYield 65.5%

Procedure

Using 1-hydroxynaphthalene-2-carboxylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-8a878aea593d4f16a267d486c86f009b
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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