Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-Bis(trifluoromethyl)phenyl]-4-hydroxyisophthalamic acid methyl ester

HRID 421071Notes

Reaction equation

HRID 421071 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:12]=[CH:11][C:10]([OH:13])=[C:6]([C:7]([OH:9])=O)[CH:5]=1.[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[NH2:20]>>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:12]=[CH:11][C:10]([OH:13])=[C:6]([C:7]([NH:20][C:19]2[CH:21]=[C:22]([C:24]([F:25])([F:26])[F:27])[CH:23]=[C:17]([C:16]([F:15])([F:28])[F:29])[CH:18]=2)=[O:9])[CH:5]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 127170602-Hydroxy-5-(methoxycarbonyl)benzoic acid

Product 1

HCID 11327249N-[3,5-Bis(trifluoromethyl)phenyl]-4-hydroxyisophthalamic acid methyl esterYield 91.5%

Procedure

Using 4-hydroxyisophthalic acid 1-methyl ester and 3,5-bis(trifluoromethyl)-aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-11e748437fb349c6855443dcb214865b
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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