Piperidine → 2-Benzyloxy-N-[3,5-bis(trifluoromethyl)phenyl]-5-(piperidine-1-carbonyl)benzamide

HRID 421076Notes

Reaction equation

HRID 421076 reaction equation
C([C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][C:9]=1[C:17]([NH:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=1)=[O:18])C1C=CC=CC=1.[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH2:12]([O:13][C:8]1[CH:16]=[CH:15][C:11]([C:12]([N:34]2[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]2)=[O:13])=[CH:10][C:9]=1[C:17]([NH:19][C:20]1[CH:25]=[C:24]([C:26]([F:28])([F:27])[F:29])[CH:23]=[C:22]([C:30]([F:31])([F:32])[F:33])[CH:21]=1)=[O:18])[C:11]1[CH:15]=[CH:16][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 865955384-benzyl-N-[3,5-bis(trifluoromethyl)phenyl]isophthalamic acid

Product 1

HCID 178601652-Benzyloxy-N-[3,5-bis(trifluoromethyl)phenyl]-5-(piperidine-1-carbonyl)benzamideYield 56.4%

Procedure

Using 4-benzyl-N-[3,5-bis(trifluoromethyl)phenyl]isophthalamic acid and piperidine as the raw materials, the same operation as the example 84(3) gave the title compound.

Sources & evidence

ORD record
ord-2412a1e8a9e5455f9e58c9314840296b
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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