4-Benzylpiperidine → 2-Benzyl-5-(4-benzylpiperidine-1-carbonyl)-N-[3,5-bis(trifluoromethyl)-phenyl]benzamide

HRID 421077Notes

Reaction equation

HRID 421077 reaction equation
[CH2:1]([C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][C:9]=1[C:17]([NH:19][C:20]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=1)=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:34]([CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH2:1]([C:8]1[CH:16]=[CH:15][C:11]([C:12]([N:44]2[CH2:45][CH2:46][CH:41]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:42][CH2:43]2)=[O:14])=[CH:10][C:9]=1[C:17]([NH:19][C:20]1[CH:21]=[C:22]([C:30]([F:31])([F:32])[F:33])[CH:23]=[C:24]([C:26]([F:29])([F:27])[F:28])[CH:25]=1)=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 317384-BenzylpiperidineHCID 865955384-benzyl-N-[3,5-bis(trifluoromethyl)phenyl]isophthalamic acid

Product 1

HCID 178601862-Benzyl-5-(4-benzylpiperidine-1-carbonyl)-N-[3,5-bis(trifluoromethyl)-phenyl]benzamideYield 76.7%

Procedure

Using 4-benzyl-N-[3,5-bis(trifluoromethyl)phenyl]isophthalamic acid and 4-benzylpiperidine as the raw materials, the same operation as the example 84(3) gave the title compound.

Sources & evidence

ORD record
ord-1b1d6bfbb0374764b0e934e9bfdb2da8
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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