Phenyl Isothiocyanate → N-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-5-[(3-phenyl)-thioureido]benzamide

HRID 421083Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([OH:25])=[C:6]([CH:24]=1)[C:7]([NH:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1)=[O:8].[C:26]1([N:32]=[C:33]=[S:34])[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:23][C:20]([F:21])([F:22])[C:12]1[CH:11]=[C:10]([NH:9][C:7](=[O:8])[C:6]2[CH:24]=[C:2]([NH:1][C:33]([NH:32][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[S:34])[CH:3]=[CH:4][C:5]=2[OH:25])[CH:15]=[C:14]([C:16]([F:17])([F:18])[F:19])[CH:13]=1

Participants

Reactant 2

HCID 7673Phenyl Isothiocyanate

HCID 10406441HCID 10406441, compound

Product 1

HCID 9983395N-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-5-[(3-phenyl)-thioureido]benzamideYield 66.3%

Procedure

Using 5-amino-N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxybenzamide and phenylisothiocyanate as the raw materials, the same operation as the example 92 gave the title compound.

Sources & evidence

ORD record: ord-b1295d582cfb4f3a848ddea42d849cac
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097759B2

Reaction notes

Loading…