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HRID42110

反应详情

EQUATION

反应方程式

HRID 42110 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CCCCC1=CC(=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID67537234

未命名化合物

结构：CC(=O)O[C@H]1CC[C@@]2(C)C(CC(=O)[C@@H]3[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]32)C1
HCID69011313

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCCCC1CC(=O)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID68950713

未命名化合物

收率 82%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

17,17-Bis(ethylendioxy)androstane-7-one was prepared in 82% yield from 3,3:17,17-bis(ethylendioxy)-5-androsten-7-one by the procedure described above for the preparation of 3β-acetoxyandrostane-7,17-dione (Prepn. 29) using EtOAc instead of EtOH. The crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4). 1H-NMR (300 MHz, acetone-d6, ppm from TMS: δ 3.96-3.75 (8H, m), 2.54-1.10 (20H, m), 1.13 (3H, s), 0.83 (3H, s).

WORKUP

后处理

  1. customThe crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4)