Hexane → 5-Bromo-4-tert-butyl-1,3-thiazol-2-amine

HRID 421163노트

반응식

HRID 421163 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1.[Br:11]N1C(=O)CCC1=O.CCCCCC>C(Cl)(Cl)(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]([Br:11])=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:6]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 67184N-bromobutanimideHCID 27342024-tert-Butyl-1,3-thiazol-2-amine

생성물 1

HCID 7291355-Bromo-4-tert-butyl-1,3-thiazol-2-amine수율 93.7%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

2-Amino-4-[(1,1-dimethyl)ethyl]thiazole (0.87 g, 5.6 mmol) was dissolved in carbon tetrachloride (9 mL). N-Bromosuccinimide (1.00 g, 5.6 mmol) was added, and the mixture was stirred at room temperature for 1 hour. Hexane was added to the reaction mixture, the insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (1.23 g, 93.7%) as a yellowish gray powder.

후처리

  1. filtrationthe insoluble matter was filtered off
  2. customthe residue obtained by evaporation of the filtrate under reduced pressure
  3. customwas purified by chromatography on silica gel (hexane:ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-6bec79217c1d4b9685713e6bf32fd114
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097759B2

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