反应详情

To a solution of [2-(phenylmethyl)hexahydropyrrolo[1,2-a]pyrazin-8a(6H)-yl]methanol (D66, 180 mg) in anhydrous methanol (5 mL) under a Nitrogen atmosphere at rt, ammonium formate (475 mg) and palladium (10% on carbon, 13 mg) were added. The resulting suspension was heated at reflux temperature for 3.5 hours, then allowed to cool to r.t. and filtered over Celite. The organic extract was dried and concentrated in vacuo to give the desired compound (120 mg) as orange waxy solid.

1. temperatureThe resulting suspension was heated
2. temperatureat reflux temperature for 3.5 hours
3. filtrationfiltered over Celite
4. extractionThe organic extract
5. customwas dried
6. concentrationconcentrated in vacuo