Trifluoroacetic acid → HCID 771666, compound

HRID 421217Notes

Reaction equation

HRID 421217 reaction equation
CC(OC([NH:8][CH2:9][CH2:10][N:11]1[CH2:19][CH2:18][CH2:17][C@H:12]1[C:13](OC)=[O:14])=O)(C)C.C(O)(C(F)(F)F)=O>ClCCl.CO>[C:13]1(=[O:14])[NH:8][CH2:9][CH2:10][N:11]2[CH2:19][CH2:18][CH2:17][C@@H:12]12

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59215781HCID 59215781, compound

Product 1

HCID 771666HCID 771666, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of methyl 1-[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)ethyl]-L-prolinate (D75, 1 g) in dichloromethane (20 ml) was added at r.t. TFA (5 ml) and the reaction mixture was stirred for 1 hr. The mixture was diluted with MeOH and it was filtered trough SCX cartridge. The fractions eluted with methanolic ammonia were evaporated in vacuo keeping the bath temperature at 40° C.

Workup

  1. filtrationwas filtered trough SCX cartridge
  2. washThe fractions eluted with methanolic ammonia
  3. customwere evaporated in vacuo
  4. customat 40° C.

Sources & evidence

ORD record
ord-5ba74867dbe04c63a607486781e398f8
Source dataset
uspto-grants-2012_01
Patent number
US08097618B2

Reaction notes

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