HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6'-[(7 S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-N,2-dimethylpropanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-[3,5-Bis(trifluoromethyl)phenyl]-n{6-fluoro-6'-[(7s,9as)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1h)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-n,2-dimethylpropanamide | HCID 16063911 | — |
| Product | 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6'-[(7 S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4'-bipyridin-3'-yl}-N,2-dimethylpropanamide hydrochloride | HCID 16063912 | — |
Reaction Steps
HCl salt made as described in example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6′-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4′-bipyridin-3′-yl}-N,2-dimethylpropanamide (E43, 11.3 mg) to afford an off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097618B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ce49cb7b33ac47f9bbfbb0193811410d |
| Source note | uspto-grants-2012_01 |