HRID421269

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1nc(F)ccc1-c1cc(N2C[C@H]3COCCN3C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID16063911

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(F)ccc1-c1cc(N2C[C@H]3COCCN3C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1.Cl

HCID16063912

未命名化合物

PROCEDURE

实验过程

HCl salt made as described in example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-fluoro-6′-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methyl-3,4′-bipyridin-3′-yl}-N,2-dimethylpropanamide (E43, 11.3 mg) to afford an off white solid.

WORKUP

后处理

customto afford an off white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce49cb7b33ac47f9bbfbb0193811410d
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08097618B2
来源说明: uspto-grants-2012_01

反应 SMILES

[ClH:1].[F:2][C:3]([F:48])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:46])([CH3:45])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[C:26]([CH3:32])=[N:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1>>[ClH:1].[F:48][C:3]([F:2])([F:47])[C:4]1[CH:5]=[C:6]([C:14]([CH3:45])([CH3:46])[C:15]([N:17]([C:19]2[CH:20]=[N:21][C:22]([N:33]3[C@H:42]([CH2:43][OH:44])[CH2:41][N:40]4[C@H:35]([CH2:36][O:37][CH2:38][CH2:39]4)[CH2:34]3)=[CH:23][C:24]=2[C:25]2[C:26]([CH3:32])=[N:27][C:28]([F:31])=[CH:29][CH:30]=2)[CH3:18])=[O:16])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1