反应详情

40% Aqueous methylamine solution (35 ml) and methanol (20 ml) were added to 5-bromo-2-chloropyrimidine (3 g, 15.5 mmol) and the resulting mixture was heated to reflux for 3 days. The mixture was cooled, then the solvent was evaporated under reduced pressure, the residue was partitioned with methylene chloride and 1 M sodium hydroxide, the organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.0 g, 100%) as a white solid.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 3 days
3. temperatureThe mixture was cooled
4. customthe solvent was evaporated under reduced pressure
5. customthe residue was partitioned with methylene chloride and 1 M sodium hydroxide
6. dry with materialthe organic layer was dried over magnesium sulfate
7. customthe solvent was evaporated under reduced pressure