反应详情

To a solution of 5-{8-[(3R)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine (100.4 mg, 0.18 mmol) in methanol/dichloromethane solution (2/3, 3.5 ml) was added methanesulfonic acid (11.9 μl, 0.18 mmol) at room temperature, and the mixture was stirred for 10 minutes. Then the solvent was removed in reduced pressure, and the resultant solid was dried to give 5-{8-[(3R)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine methanesulfonate (107.1 mg) as a yellow solid.

1. customThen the solvent was removed in reduced pressure
2. customthe resultant solid was dried