反应详情

Trifluoroacetic acid (5 ml) was added to tert-butyl{5-[8-{4-[(dimethylamino)(oxo)acetyl]piperazin-1-yl}-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-yl}carbamate (148 mg, 0.22 mmol) and the resulting mixture was stirred for 30 minutes. Toluene was added and the solvent was evaporated under reduced pressure. Hydrochloric acid-methanol was added to the residue and the solvent was evaporated and dried to give the title compound (118 mg, 88%) as a yellow solid.

1. customthe solvent was evaporated under reduced pressure
2. additionHydrochloric acid-methanol was added to the residue
3. customthe solvent was evaporated
4. customdried