Hydroxylamine → HCID 178504809, compound

HRID 42146Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:26]=[CH:25][C:8]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23]#[N:24])[CH2:19][CH2:18]3)=[CH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:27][OH:28]>C(O)C>[OH:28][NH:27][C:23]([N:20]1[CH2:21][CH2:22][CH:17]([C:14]2[CH:15]=[CH:16][C:11]([CH2:10][O:9][C:8]3[CH:25]=[CH:26][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=3)=[N:12][CH:13]=2)[CH2:18][CH2:19]1)=[NH:24]

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of 4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-carbonitrile (92 mg, 0.248 mmol) in ethanol (0.8 mL) was added 50% hydroxylamine solution (0.2 mL). The mixture was stirred at 60° C. for 4 hours, allowed to cool to room temperature and concentrated under reduced pressure to give the title compound (98 mg, yield 98%).

Workup

temperatureto cool to room temperature
concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-1c45ef6347f247e1a40ce36aaf321be1
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08536176B2

Reaction notes

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