Hydrochloric Acid → HCID 12000685, compound

Participants

Reaction Steps

A 183 mg portion of pyridine-2-carbothioamide hydrochloride and 209 mg of calcium carbonate were added at room temperature to a 2-propanol solution (20 ml) of 340 mg of 2-bromo-1-(1-naphthyl)-2-phenylethanone and heated overnight under reflux. The reaction liquid was acidified by adding 1 M hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated under a reduced pressure. The thus obtained residue was purified by a silica gel column chromatography using ethyl acetate:n-hexane (1:9) as the elution solvent, thereby obtaining 227 mg of 2-[4-(1-naphthyl)-5-phenyl-1,3-thiazol-2-yl]pyridine as a colorless solid.

Provenance & Evidence