反应详情

温度

27.5 °C

Quetiapine free base (5.0 g) was dissolved in isopropyl alcohol (50 ml) at room temperature. This was followed by addition of 98% sulfuric acid (1.28 g) at 30 to 35° C. The resulting gummy mass was heated to reflux and maintained for 15 minutes. The resulting mass was cooled at 25-30° C. and stirred for 1 hour. The precipitated product was collected by filtration, washed with isopropyl alcohol (25 ml) and dried to give the title compound as off white powder (5.88 g).

1. temperatureThe resulting gummy mass was heated
2. temperatureto reflux
3. temperaturemaintained for 15 minutes
4. filtrationThe precipitated product was collected by filtration
5. washwashed with isopropyl alcohol (25 ml)
6. customdried