HCID 57639405, compound → HCID 57639279, compound

HRID 421601Notes

Reaction equation

HRID 421601 reaction equation
[CH3:1][CH:2]([NH:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([NH:21][C:22]3[C:27]([F:28])=[CH:26][C:25]([F:29])=[CH:24][C:23]=3[F:30])[N:11]2[C@@H:14]([CH3:20])[CH2:15][CH2:16][C:17]([NH2:19])=[O:18])=[CH:7][N:6]=1)[CH3:3].CC(NC1N=C2C(N=C(NC3C(F)=CC(F)=CC=3F)N2[C@H](C)CCC(OC)=O)=CN=1)C>>[CH3:3][CH:2]([NH:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([NH:21][C:22]3[C:23]([F:30])=[CH:24][C:25]([F:29])=[CH:26][C:27]=3[F:28])[N:11]2[C@H:14]([CH3:20])[CH2:15][CH2:16][C:17]([NH2:19])=[O:18])=[CH:7][N:6]=1)[CH3:1]

Participants

3

Reactant 2

HCID 57639405HCID 57639405, compoundHCID 66672674HCID 66672674, compound

Product 1

HCID 57639279HCID 57639279, compoundYield 57%

Procedure

The title compound was prepared as (4S)-4-{2-[(methylethyl)amino]-8-[(2,4,6-trifluorophenyl)amino]purin-9-yl}pentanamide with methyl (4R)-4-{2-[(methylethyl)amino]-8-[(2,4,6-trifluorophenyl)amino]purin-9-yl}pentanoate (500 mg, 1.15 mmol) to give the title compound (273 mg, 57%): ES-MS (m/z) 422.3 [M+1]+.

Sources & evidence

ORD record
ord-9f7e7391822d42d8972223628f610477
Source dataset
uspto-grants-2012_01
Patent number
US08101588B2

Reaction notes

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