HCID 44820148, compound → HCID 67223777, compound

HRID 42161Notes

Reaction equation

HRID 42161 reaction equation
[C:1]([C:3]1[CH:29]=[CH:28][C:6]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:20][CH2:19][N:18]([C:21](OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[CH:11][N:10]=2)=[CH:5][C:4]=1[F:30])#[N:2].[CH2:31]([C:36]1[CH:37]=[N:38]C(Br)=[N:40][CH:41]=1)[CH2:32][CH2:33][CH2:34][CH3:35]>>[C:1]([C:3]1[CH:29]=[CH:28][C:6]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:20][CH2:19][N:18]([C:21]4[N:40]=[CH:41][C:36]([CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:37][N:38]=4)[CH2:17][CH2:16]3)=[CH:11][N:10]=2)=[CH:5][C:4]=1[F:30])#[N:2]

Participants

3

Reactant 2

HCID 44820148HCID 44820148, compoundHCID 866542665-Pentyl-2-bromopyrimidine

Product 1

HCID 67223777HCID 67223777, compound

Procedure

The title compound was prepared from tert-butyl 4-[2-(4-cyano-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate (Example 13) (33 mg, 0.08 mmol) and 5-pentyl-2-bromopyrimidine (27 μL, 0.16 mmol) following a procedure analogous to that in Example 48 as a white crystal (24 mg, yield 65%).

Sources & evidence

ORD record
ord-6e0a66a316574685985f5e43e91c68ad
Source dataset
uspto-grants-2013_09
Patent number
US08536176B2

Reaction notes

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