反应详情

温度

80 °C

To an 80° C. heated mixture of trans-4-Aminocyclohexanecarboxylic acid (8 g, 55.97 mmol) and K2C03 (23.4 g) in 112 mL of CH3CN, was added dropwise a solution of BnBr (23.3 mL, 195.5 mmol) in 70 mL of CH3CN by addition funnel. Reaction stirred overnight at 80° C. The reaction was cooled to room temperature and filtered. Precipitate did not form in filtrate like it did with the cis-somer so the filtrate was concentrated to an oil and carried on to next step (23.01 g, 99% yield).

1. additionby addition funnel
2. customReaction
3. temperatureThe reaction was cooled to room temperature
4. filtrationfiltered
5. customPrecipitate did not form in filtrate like it
6. concentrationwas concentrated to an oil