HCID 67083200, compound → 5-Pentyl-2-[4-[2-[4-(tetrazol-1-yl)phenoxymethyl]pyridin-5-yl]piperidin-1-yl]pyrimidine
Reaction equation
[N:1]1([C:6]2[CH:32]=[CH:31][C:9]([O:10][CH2:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][N:21]([C:24](OC(C)(C)C)=O)[CH2:20][CH2:19]4)=[CH:14][N:13]=3)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.[CH2:33]([C:38]1[CH:39]=[N:40]C(Br)=[N:42][CH:43]=1)[CH2:34][CH2:35][CH2:36][CH3:37]>>[CH2:33]([C:38]1[CH:39]=[N:40][C:24]([N:21]2[CH2:22][CH2:23][CH:18]([C:15]3[CH:16]=[CH:17][C:12]([CH2:11][O:10][C:9]4[CH:8]=[CH:7][C:6]([N:1]5[CH:5]=[N:4][N:3]=[N:2]5)=[CH:32][CH:31]=4)=[N:13][CH:14]=3)[CH2:19][CH2:20]2)=[N:42][CH:43]=1)[CH2:34][CH2:35][CH2:36][CH3:37]Participants
3
Procedure
The title compound was prepared from tert-butyl 4-[2-[4-(tetrazol-1-yl)phenoxymethyl]pyridin-5-yl]piperidine-1-carboxylate (Example 17) (52 mg, 0.12 mmol) and 5-pentyl-2-bromopyrimidine (41 μL, 0.24 mmol) following a procedure analogous to that in Example 48 as a white crystal (26 mg, yield 45%).
Sources & evidence
- ORD record
- ord-e272d0b746cf4d2b8ffca9ca85ebe692
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536176B2
Reaction notes
Loading…