HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → 2-Amino-9-(2-(tert-butyldimethylsilyloxy)ethyl)-9H-pyrido[2,3-b]indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Reactant | 2-amino-9-isopropyl-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 24900676 | — |
| Product | 2-Amino-9-(2-(tert-butyldimethylsilyloxy)ethyl)-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 59513646 | — |
Reaction Steps
2-Amino-9-(2-(tert-butyldimethylsilyloxy)ethyl)-9H-pyrido[2,3-b]indole-3-carboxamide (xxv-a) was prepared following the procedure detailed in the synthesis of 13 substituting (2-bromoethoxy)(tert-butyl)dimethylsilane for 2-bromopropane. The crude silane was used in the following step without further purification. NH4OAc QC conditions. M+H=385.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101604B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9010bb44d1474487b3dc7939f2d52f89 |
| Source note | uspto-grants-2012_01 |