HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methylpiperazin-1-yl)benzoic acid → N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methylpiperazin-1-yl)benzoic acid | HCID 736532 | — |
| Reactant | N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide | HCID 16730560 | — |
| Product | N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide | HCID 16730714 | — |
Reaction Steps
N-(3-amino-4-chlorophenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.15 mmol) was used in general procedure 2 with 4-(4-methylpiperazin-1-yl)benzoic acid (0.167 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(4-(4-methylpiperazin-1-yl)benzamido)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 532.0 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101610B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-a3bfcaa7085843a3bb302caec3b4a782 |
| Source note | uspto-grants-2012_01 |