1-Ethylpiperazine → HCID 16730871, compound

HRID 421686Notes

Reaction equation

HRID 421686 reaction equation
[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:26])[C:19]2[CH:24]=[CH:23][C:22](Cl)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:27]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)[CH3:28]>>[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:26])[C:19]2[CH:24]=[CH:23][C:22]([N:32]3[CH2:33][CH2:34][N:29]([CH2:27][CH3:28])[CH2:30][CH2:31]3)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 16730795HCID 16730795, compound

Product 1

HCID 16730871HCID 16730871, compound

Procedure

N-(3-benzamido-4-chlorophenyl)-6-chloronicotinamide (0.15 mmol) was used in general procedure 3 with 1-ethylpiperazin (0.77 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(4-ethylpiperazin-1-yl)nicotinamide. MS (Q1) 464.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-bd5e9e7470fc4e13b8be9e86c313b7cd
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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