N-(5-amino-2-chlorophenyl)benzamide → N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide

HRID 421693Notes

Reaction equation

HRID 421693 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:17])=[C:6]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1.[Br:18][CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][N:21]=1>>[C:9]([NH:8][C:6]1[CH:7]=[C:2]([NH:1][C:24](=[O:25])[C:23]2[CH:27]=[CH:28][C:20]([CH2:19][Br:18])=[N:21][CH:22]=2)[CH:3]=[CH:4][C:5]=1[Cl:17])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 721122N-(5-amino-2-chlorophenyl)benzamideHCID 218409786-(Bromomethyl)-3-pyridinecarboxylic acid

Product 1

HCID 16730952N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide

Procedure

N-(5-amino-2-chlorophenyl)benzamide (1.0 mmol) was used in general procedure 2 with 6-(bromomethyl)nicotinic acid (21.1 mmol) to give N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)-nicotinamide. MS (Q1) 444.0 (M)+

Sources & evidence

ORD record
ord-c7b02a9d77324492aee2182a07c40ef0
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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