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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 421696Generated: October 31, 2026

1-Methylpiperazine → N-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamide

https://huagongshe.com/reaction/421696

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
ReactantN-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamideHCID 16730952—
ProductN-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamideHCID 16731030—

Reaction Steps

N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide (0.11 mmol) was used in general procedure 5 with 1-methylpiperazin (0.12 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamide. MS (Q1) 464.0 (M)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08101610B2
Source datasetuspto-grants-2012_01
ORD IDord-d4bf7b3f243f48fcb01f6218bc76c723
Source noteuspto-grants-2012_01