1-Methylpiperazine → N-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamide

HRID 421696Notes

Reaction equation

HRID 421696 reaction equation
[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([CH2:25]Br)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[C:1]([NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:27])[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][N:32]3[CH2:33][CH2:34][N:29]([CH3:28])[CH2:30][CH2:31]3)=[N:21][CH:20]=2)[CH:13]=[CH:14][C:15]=1[Cl:16])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 16730952N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide

Product 1

HCID 16731030N-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamide

Procedure

N-(3-benzamido-4-chlorophenyl)-6-(bromomethyl)nicotinamide (0.11 mmol) was used in general procedure 5 with 1-methylpiperazin (0.12 mmol). The product was purified by RP-HPLC to give N-(3-benzamido-4-chlorophenyl)-6-(4-methylpiperazin-1-ylmethyl)nicotinamide. MS (Q1) 464.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-d4bf7b3f243f48fcb01f6218bc76c723
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

Loading…