rel-(2R,6S)-2,6-dimethylpiperazine → 2-Methylnicotinamide

HRID 421707Notes

Reaction equation

HRID 421707 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC(F)=CC=3)C=2)=[O:7])=[C:4]([CH3:28])[N:3]=1.C[C@H]1CNC[C@@H](C)N1>>[CH3:28][C:4]1[N:3]=[CH:2][CH:27]=[CH:26][C:5]=1[C:6]([NH2:8])=[O:7]

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 16731197HCID 16731197, compound

Product 1

HCID 122437052-Methylnicotinamide

Procedure

6-chloro-N-(4-chloro-3-(4-fluorobenzamido)phenyl)-2-methylnicotinamide (0.15 mmol) was used in general procedure 3 with cis-2,6-dimethylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give N-(4-fluorobenzamido)phenyl))-6-(3S-,5R)-3-5-dimethylpiperazine-1-yl)-2-methylnicotinamide. MS (Q1) 496.0 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-b47ecec2430140379d6edf9782374611
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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