rel-(2R,6S)-2,6-dimethylpiperazine → 2-Methylnicotinamide

Participants

Role	Name	HCID	Charge
Reactant	rel-(2R,6S)-2,6-dimethylpiperazine	HCID 6950261	—
Reactant	HCID 16731197	HCID 16731197	—
Product	2-Methylnicotinamide	HCID 12243705	—

Reaction Steps

6-chloro-N-(4-chloro-3-(4-fluorobenzamido)phenyl)-2-methylnicotinamide (0.15 mmol) was used in general procedure 3 with cis-2,6-dimethylpiperazine (0.77 mmol). The product was purified by RP-HPLC to give N-(4-fluorobenzamido)phenyl))-6-(3S-,5R)-3-5-dimethylpiperazine-1-yl)-2-methylnicotinamide. MS (Q1) 496.0 (M)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08101610B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-b47ecec2430140379d6edf9782374611
Source note	uspto-grants-2012_01