1-Ethylpiperazine → HCID 69050101, compound

HRID 421715Notes

Reaction equation

Br[CH2:2][C:3]1[CH:28]=[CH:27][C:6]([C:7]([NH:9]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:8])=[CH:5][N:4]=1.[CH2:29]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)[CH3:30]>>[CH2:29]([N:31]1[CH2:36][CH2:35][N:34]([CH2:2][C:3]2[CH:28]=[CH:27][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][N:4]=2)[CH2:33][CH2:32]1)[CH3:30]

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 16731357HCID 16731357, compound

Product 1

HCID 69050101HCID 69050101, compound

Procedure

6-(bromomethyl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.2 mmol) was used in general procedure 5 with 1-ethylpiperazine (0.4 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(3-chlorobenzamido)phenyl))-6-(4-ethylpiperazin-1-yl)methylnicotinamide. MS (Q1) 512.2 (M)+

Workup

customThe product was purified by RP-HPLC

Sources & evidence

ORD record: ord-c4357bb4e93c48298f08da7b7b9ee28d
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

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