1-Acetylpiperazine → 2-Methylnicotinamide

HRID 421719Notes

Reaction equation

Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:7])=[C:4]([CH3:28])[N:3]=1.C(N1CCNCC1)(=O)C>>[CH3:28][C:4]1[N:3]=[CH:2][CH:27]=[CH:26][C:5]=1[C:6]([NH2:8])=[O:7]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 16730160HCID 16730160, compound

Product 1

HCID 122437052-Methylnicotinamide

Procedure

6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)-2-methylnicotinamide (0.16 mmol) was used in general procedure 3 with 1-acetylpiperazine (0.83 mmol). The product was purified by RP-HPLC to give 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(3-chlorobenzamido)phenyl))phenyl)-2-methylnicotinamide. MS (Q1) 526.1 (M)+

Workup

customThe product was purified by RP-HPLC

Sources & evidence

ORD record: ord-51c013fc20874a959b616eb984f66299
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08101610B2

Reaction notes

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