2-Chlorobenzoic Acid → HCID 16730381, compound

HRID 421729Notes

Reaction equation

HRID 421729 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[N:13][CH:12]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](O)=[O:23]>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]([NH:9][C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([NH:1][C:22](=[O:23])[C:21]3[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=3[Cl:19])[CH:3]=2)=[O:18])=[CH:12][N:13]=1

Participants

3

Reactant 2

HCID 83742-Chlorobenzoic AcidHCID 86624156HCID 86624156, compound

Product 1

HCID 16730381HCID 16730381, compound

Procedure

N-(3-amino-4-chlorophenyl)-6-chloronicotinamide (0.2 mmol) was used in general procedure 2 with 2-chlorobenzoic acid (0.8 mmol). The product was purified by RP-HPLC to give 6-chloro-N-(4-chloro-3-(2-chlorobenzamido)phenyl)nicotinamide. MS (Q1) 419.8 (M)+

Workup

  1. customThe product was purified by RP-HPLC

Sources & evidence

ORD record
ord-b086adb9b15e43b6ab0d824c57d5e93a
Source dataset
uspto-grants-2012_01
Patent number
US08101610B2

Reaction notes

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