反应详情

tert.-Butyl [6-(4-cyanophenyl)-5-(cyclobutylcarbonyl)-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-1(2H)-yl]acetate (Example 26) (35 mg, 0.063 mmol) is dissolved in trifluoroacetic acid (1 ml). After 5 minutes stirring, the solution is concentrated in vacuo and the residue is purified by HPLC (RP18 column; eluent: acetonitrile/0.1% aq. formic acid 10:90→90:10).

1. concentrationthe solution is concentrated in vacuo
2. customthe residue is purified by HPLC (RP18 column; eluent: acetonitrile/0.1% aq. formic acid 10:90→90:10)