HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 66674083, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-N,N-diethylethanamine | HCID 70608 | — |
| Reactant | 4-{5-(Cyclohexylcarbonyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}benzonitrile | HCID 59684783 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66674083 | HCID 66674083 | — |
Reaction Steps
To a stirred solution of Example 21 (780 mg, 1.67 mmol) in THF (25 ml) is added sodium hydride (60% dispersion in mineral oil; 653 mg, 2.53 mmol). The mixture is stirred for 1 hour at room temperature, then 2-bromo-N,N-diethylethanamine (653 mg, 2.53 mmol) is added, and the solution is stirred overnight (16 h) at room temperature. The reaction mixture is quenched with methanol (10 ml), concentrated, and the crude product is purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08101615B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-687052fa5a1d4a5e90cd74506f7ac943 |
| Source note | uspto-grants-2012_01 |