反应详情

To a stirred solution of Example 21 (780 mg, 1.67 mmol) in THF (25 ml) is added sodium hydride (60% dispersion in mineral oil; 653 mg, 2.53 mmol). The mixture is stirred for 1 hour at room temperature, then 2-bromo-N,N-diethylethanamine (653 mg, 2.53 mmol) is added, and the solution is stirred overnight (16 h) at room temperature. The reaction mixture is quenched with methanol (10 ml), concentrated, and the crude product is purified by preparative HPLC.

1. stirringthe solution is stirred overnight (16 h) at room temperature
2. customThe reaction mixture is quenched with methanol (10 ml)
3. concentrationconcentrated
4. customthe crude product is purified by preparative HPLC