Ammonia → HCID 11992803, compound

HRID 421827Notes

Reaction equation

HRID 421827 reaction equation
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:23])[CH2:18][CH2:17]3)[CH:11]=2)[N:6]=1)=O.[NH3:30]>C1(C)C=CC=CC=1>[C:3]([C:5]1[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([N:16]3[CH2:17][CH2:18][N:19]([C:22]([O:24][CH2:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:23])[CH2:20][CH2:21]3)[CH:11]=2)[N:6]=1)(=[O:2])[NH2:30]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11992707HCID 11992707, compound

Product 1

HCID 11992803HCID 11992803, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2,2-Dimethylpropyl 4-{4-[5-(methoxycarbonyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}-1-piperazinecarboxylate (86.5 mg) obtained in Example 31 was dissolved in toluene (1 mL), and aqueous ammonia (0.3 mL) was added thereto and stirred at room temperature for 4 hours. Then, the solvent was evaporated away, and the resulting residue was isolated and purified through thin-layer silica gel chromatography (chloroform/methanol=97/3) to obtain 40 mg of the entitled compound as a colorless solid.

Workup

  1. customThen, the solvent was evaporated away
  2. customthe resulting residue was isolated
  3. custompurified through thin-layer silica gel chromatography (chloroform/methanol=97/3)

Sources & evidence

ORD record
ord-e15da9b99e3a43e2ac17659893723141
Source dataset
uspto-grants-2012_01
Patent number
US08101618B2

Reaction notes

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