反应详情

Thioacetamide (120 mg) was added to an ethanol (6 mL) solution of tert-butyl 4-(bromoacetyl)piperazinecarboxylate (340 mg) obtained in the above 1), and heated under reflux for 3 hours. The reaction liquid was restored to room temperature, then the solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=7/3) to obtain 7 mg of the entitled compound.

1. customobtained in the above 1), and
2. temperatureheated
3. temperatureunder reflux for 3 hours
4. customThe reaction liquid
5. customwas restored to room temperature
6. customthe solvent was evaporated away under reduced pressure
7. customthe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=7/3)