反应详情

Using the general protocol, 1-benzyl-4-piperazin-1-yl-phthalazine (56 mg, 0.184 mmol) and 2-chloro-5-cyanopyrimidine (44.5 mg, 0.239 mmol) are added into a microwave vial, equipped with a stir bar, and MeCN (0.5 ml) and NMP (0.5 ml) are dispensed. The vial is sealed and the reaction was irradiated at high level absorption in the microwave at 180° C. for 15 min. The product is observed as the main peak (m/z; M+1=408). The compound is purified by preparative HPLC using a C8-254 nm method.

1. additionare added into a microwave vial
2. customequipped with a stir bar
3. customThe vial is sealed
4. customthe reaction was irradiated at high level absorption in the microwave at 180° C. for 15 min
5. customThe compound is purified by preparative HPLC