反应详情

温度

85 °C

A mixture of 4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylic acid methyl ester (3.83 g, 15.6 mmol) and phosphorous oxychloride (50 mL) was heated to 85° C. After 20 hours, the reaction mixture was concentrated under reduced pressure. The resulting residue was quenched with water. The precipitate was filtered and dissolved in EtOAc, dried (MgSO4) and concentrated under reduced pressure to yield 3.44 g (84%) of desired product.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. customThe resulting residue was quenched with water
3. filtrationThe precipitate was filtered
4. dissolutiondissolved in EtOAc
5. dry with materialdried (MgSO4)
6. concentrationconcentrated under reduced pressure