反应详情

4-(4-Benzyl-phthalazin-1-yl)-5′-isopropenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (50 mg, 0.118 mmol) is dissolved in MeOH (2 mL). Palladium hydroxide (25 mg) is added to the flask capped with a septum and balloon of hydrogen. The reaction is stirred 3 h at room temperature. Filter through a small pad of silica gel and wash behind with EtOAc. Concentrate the filtrate in vacuo. The residue is purified by flash chromatography on silica gel (EtOAc/Heptane) to afford the title compound (17.6 mg, 35%).

1. filtrationFilter through a small pad of silica gel
2. washwash behind with EtOAc
3. concentrationConcentrate the filtrate in vacuo
4. customThe residue is purified by flash chromatography on silica gel (EtOAc/Heptane)