反应详情

Dissolve 4-(4-Benzyl-phthalazin-1-yl)-5′-isopropenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (100 mg, 0.237 mmol) in acetone (1.5 mL), t-Butanol (0.7 mL) and water (0.7 mL). Add K2OsO4 (0.79 mg, 0.0024 mmol) then NMO (30.5 mg, 0.26 mmol) and stir reaction for 16 h at room temperature. Quench with saturated sodium sulfite (1 mL) and extract with EtOAc. The residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2) to afford the title compound (100 mg, 92%).

1. customreaction for 16 h at room temperature
2. customQuench with saturated sodium sulfite (1 mL)
3. extractionextract with EtOAc
4. customThe residue is purified by flash chromatography on silica gel (MeOH/CH2Cl2)